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Thonzonium Bromide

Name: Thonzonium Bromide
Brand: TargetMol
SKU: T2188
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2188Cas No. 553-08-2

Thonzonium bromide is a mono-cationic surfactant that is structurally similar to Farnesol as an antimicrobial agent. It inhibits proton transport in a dose-dependent manner (EC50=69 μM). It inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo.

Thonzonium Bromide

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Purity: 99.94%

Catalog No. T2188Cas No. 553-08-2

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$47	In Stock	In Stock
25 mg	$94	In Stock	In Stock
50 mg	$178	In Stock	In Stock
100 mg	$268	In Stock	In Stock
500 mg	$663	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Color:White

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Product Introduction

Thonzonium Bromide AI Summary

Thonzonium Bromide demonstrates bioactivity across multiple biological pathways and exhibits inhibition of various viral, bacterial, and fungal targets. It shows significant potency in inhibiting proteins such as ubiquitin-specific protease USP2a, mitochondrial division and fusion regulators, lipid storage modulators, and enzymes like AmpC Beta-Lactamase. It is effective in modulating glucocerebrosidase activity for Gaucher Disease treatment and shows high inhibition activity on proteins such as Nrf2, TDP1, FEN1, and Beta Cell apoptosis. Thonzonium Bromide binds competitively to the human pregnane X receptor (PXR), activating it in human liver cells and inducing CYP3A4 enzyme expression with a 36.0% induction at an EC50 value of 11200.0 nM. It exhibits antibiofilm activity against Candida albicans with an IC50 value of 13000.0 nM, and antiviral activity by inhibiting SARS-CoV-2-induced cytotoxicity in both Caco-2 and VERO-6 cells, with significant inhibition rates. The compound shows high efficacy against bacterial strains, demonstrating cytotoxicity against Salmonella Typhimurium and Salmonella typhi, and strong inhibition against Escherichia coli GroEL and GroES proteins, leading to a reduction in the refolding of denatured rhodanese and soluble pig heart MDH enzymes, with inhibition rates of 98.0% and 100.0%, respectively. Additionally, Thonzonium Bromide exhibits inhibitory activity against the SARS-CoV-2 3CL-Pro protease and demonstrates activity against Mycobacterium tuberculosis H37Rv..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	591.71
Formula	C₃₂H₅₅BrN₄O
Cas No.	553-08-2
Smiles	[Br-].CCCCCCCCCCCCCCCC[N+](C)(C)CCN(Cc1ccc(OC)cc1)c1ncccn1
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 260 mg/mL (439.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6900 mL	8.4501 mL	16.9002 mL	84.5009 mL
5 mM	0.3380 mL	1.6900 mL	3.3800 mL	16.9002 mL
10 mM	0.1690 mL	0.8450 mL	1.6900 mL	8.4501 mL
20 mM	0.0845 mL	0.4225 mL	0.8450 mL	4.2250 mL
50 mM	0.0338 mL	0.1690 mL	0.3380 mL	1.6900 mL
100 mM	0.0169 mL	0.0845 mL	0.1690 mL	0.8450 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc